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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK5
All Species:
36.67
Human Site:
Y239
Identified Species:
57.62
UniProt:
Q00535
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00535
NP_004926.1
292
33304
Y239
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
T
Chimpanzee
Pan troglodytes
XP_001149427
306
35062
S240
Q
L
P
D
Y
K
G
S
F
P
K
W
T
R
K
Rhesus Macaque
Macaca mulatta
XP_001102502
306
34957
N240
Q
L
P
D
Y
K
G
N
F
P
K
W
T
R
K
Dog
Lupus familis
XP_532760
331
37322
Y278
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
T
Cat
Felis silvestris
Mouse
Mus musculus
P49615
292
33270
Y239
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
T
Rat
Rattus norvegicus
Q03114
292
33236
Y239
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001129258
292
33321
Y239
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
T
Frog
Xenopus laevis
P51166
292
33320
Y239
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
M
Zebra Danio
Brachydanio rerio
NP_571794
292
33381
Y239
K
L
P
D
Y
K
P
Y
P
M
Y
P
A
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48609
294
33162
L239
H
L
S
D
Y
V
A
L
P
S
F
P
A
I
T
Honey Bee
Apis mellifera
XP_391878
299
34094
F239
T
L
P
D
Y
K
P
F
P
L
Y
H
P
A
Q
Nematode Worm
Caenorhab. elegans
NP_499783
292
33044
Y239
Q
L
P
D
Y
K
P
Y
P
I
Y
H
P
T
L
Sea Urchin
Strong. purpuratus
XP_001200386
295
33676
Y240
K
L
P
D
F
K
P
Y
P
I
Y
P
V
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
A240
C
L
P
D
F
K
T
A
F
P
R
W
Q
A
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
A240
S
L
P
D
Y
K
S
A
F
P
K
W
K
P
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.1
58.8
86.7
N.A.
99.6
99.3
N.A.
N.A.
97.2
96.9
96.5
N.A.
77.5
81.9
73.6
67.1
Protein Similarity:
100
75.1
75.1
87.9
N.A.
100
99.6
N.A.
N.A.
98.9
98.9
98.9
N.A.
86.7
89.3
86.9
78.9
P-Site Identity:
100
33.3
33.3
100
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
46.6
53.3
66.6
80
P-Site Similarity:
100
40
40
100
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
53.3
66.6
80
93.3
Percent
Protein Identity:
N.A.
57.8
N.A.
56.4
N.A.
N.A.
Protein Similarity:
N.A.
76.8
N.A.
75.5
N.A.
N.A.
P-Site Identity:
N.A.
26.6
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
14
0
0
0
0
54
14
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
14
0
0
7
27
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
14
0
0
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
14
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
14
0
0
0
7
0
% I
% Lys:
54
0
0
0
0
94
0
0
0
0
20
0
7
0
14
% K
% Leu:
0
100
0
0
0
0
0
7
0
7
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
47
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
94
0
0
0
67
0
74
27
0
60
14
7
0
% P
% Gln:
20
0
0
0
0
0
0
0
0
0
0
0
7
0
14
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
7
0
0
14
0
% R
% Ser:
7
0
7
0
0
0
7
7
0
7
0
0
0
0
0
% S
% Thr:
7
0
0
0
0
0
7
0
0
0
0
0
14
60
60
% T
% Val:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
27
0
0
0
% W
% Tyr:
0
0
0
0
87
0
0
60
0
0
67
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _